Search Results
Overview
| Uniprot ID | Q93099 |
|---|---|
| Protein Name | Homogentisate 1,2-dioxygenase |
| Gene Name | HGD |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | IPKASQKKVDFVSGL |
| 248 | GGYTVINKYQGKLFA |
| 252 | VINKYQGKLFAAKQD |
| 353 | IRGHYEAKQGGFLPG |
| 385 | FEKASKVKLAPERIA |
Function
Catalyzes the conversion of homogentisate to maleylacetoacetate
Protein Sequence
10
MAELKYISGF
20
GNECSSEDPR
30
CPGSLPEGQN
40
NPQVCPYNLY
50
AEQLSGSAFT
60
CPRSTNKRSW
70
LYRILPSVSH
80
KPFESIDEGQ
90
VTHNWDEVDP
100
DPNQLRWKPF
110
EIPKASQKKV
120
DFVSGLHTLC
130
GAGDIKSNNG
140
LAIHIFLCNT
150
SMENRCFYNS
160
DGDFLIVPQK
170
GNLLIYTEFG
180
KMLVQPNEIC
190
VIQRGMRFSI
200
DVFEETRGYI
210
LEVYGVHFEL
220
PDLGPIGANG
230
LANPRDFLIP
240
IAWYEDRQVP
250
GGYTVINKYQ
260
GKLFAAKQDV
270
SPFNVVAWHG
280
NYTPYKYNLK
290
NFMVINSVAF
300
DHADPSIFTV
310
LTAKSVRPGV
320
AIADFVIFPP
330
RWGVADKTFR
340
PPYYHRNCMS
350
EFMGLIRGHY
360
EAKQGGFLPG
370
GGSLHSTMTP
380
HGPDADCFEK
390
ASKVKLAPER
400
IADGTMAFMF
410
ESSLSLAVTK
420
WGLKASRCLD
430
ENYHKCWEPL
440
KSHFTPNSRN
PAEPN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0004411 | homogentisate 1,2-dioxygenase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006559 | L-phenylalanine catabolic process |
| Biological Process | GO:0006572 | L-tyrosine catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.