Search Results
Overview
| Uniprot ID | Q948T6 |
|---|---|
| Protein Name | Lactoylglutathione lyase |
| Gene Name | Os08g0191700 |
| Organism | Oryza sativa subsp. japonica |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 185 | GMKLLRKKDVPDYKY |
| 19 | EVVLEWPKKDKKRLL |
| 40 | GDLDRTIKCYTECFG |
Function
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (By similarity). Involved in the detoxifiation of methylglyoxal. Can functionally complement growth defect of a yeast mutant lacking GLY I. Involved in abiotic stress response. Over-expression of GLYI-11 in tobacco increases tolerance to osmotic, oxidative and salt stresses (PubMed:24661284)
Protein Sequence
10
MASGSEAEKS
20
PEVVLEWPKK
30
DKKRLLHAVY
40
RVGDLDRTIK
50
CYTECFGMKL
60
LRKRDVPEEK
70
YTNAFLGFGP
80
EDTNFALELT
90
YNYGVDKYDI
100
GAGFGHFAIA
110
TEDVYKLAEK
120
IKSSCCCKIT
130
REPGPVKGGS
140
TVIAFAQDPD
150
GYMFELIQRG
160
PTPEPLCQVM
170
LRVGDLDRSI
180
KFYEKALGMK
190
LLRKKDVPDY
200
KYTIAMLGYA
210
DEDKTTVIEL
220
TYNYGVTEYT
230
KGNAYAQVAI
240
GTEDVYKSAE
250
AVELVTKELG
260
GKILRQPGPL
270
PGLNTKIASF
280
LDPDGWKVVL
290
VDNADFLKEL
Q
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0019863 | IgE binding |
| Molecular Function | GO:0004462 | lactoylglutathione lyase activity |
| Molecular Function | GO:0016151 | nickel cation binding |
| Biological Process | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione |
| Biological Process | GO:0006970 | response to osmotic stress |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0009651 | response to salt stress |
Reference
[1] Meng X, Baine JM, Yan T, Wang S. Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains.. J Agric Food Chem 69(29):8287-8297. 2021 Jul 28. PMID: 34264677.