Overview
| Uniprot ID | Q95250 |
|---|
| Protein Name | Membrane-associated progesterone receptor component 1 |
|---|
| Gene Name | PGRMC1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 101 |
GKVFDVTKGRKFYGP |
| 104 |
FDVTKGRKFYGPEGP |
Function
Component of a progesterone-binding protein complex. Binds progesterone (By similarity). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (By similarity). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (By similarity)
Protein Sequence
10
MAAEDVAATG
20
ADPSELEGGG
30
LLHEIFTSPL
40
NLLLLGLCIF
50
LLYKIVRGDQ
60
PAASDSDDDE
70
PPPLPRLKRR
80
DFTPAELRRF
90
DGVQDPRILM
100
AINGKVFDVT
110
KGRKFYGPEG
120
PYGVFAGRDA
130
SRGLATFCLD
140
KEALKDEYDD
150
LSDLTPAQQE
160
TLNDWDSQFT
170
FKYHHVGKLL
180
KEGEEPTVYS
190
DEEEPKDESA
RKND
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0012505 |
endomembrane system |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0030868 |
smooth endoplasmic reticulum membrane |
| Molecular Function |
GO:0020037 |
heme binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0005496 |
steroid binding |
| Biological Process |
GO:0006783 |
heme biosynthetic process |
| Biological Process |
GO:0140077 |
positive regulation of lipoprotein transport |
| Biological Process |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.