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Overview

Uniprot IDQ95274
Protein NameThymosin beta-4
Gene NameTMSB4
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
12 PDMAEIEKFDKSKLK
26 KKTETQEKNPLPSKE
32 EKNPLPSKETIEQEK
39 KETIEQEKQAGES**
4 ****MSDKPDMAEIE

Function

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization

Protein Sequence

10 MSDKPDMAEI 20 EKFDKSKLKK 30 TETQEKNPLP 40 SKETIEQEKQ AGES

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003785 actin monomer binding
Molecular Function GO:0140311 protein sequestering activity
Biological Process GO:0007015 actin filament organization
Biological Process GO:0030334 regulation of cell migration

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.