Overview
| Uniprot ID | Q969G5 |
|---|
| Protein Name | Caveolae-associated protein 3 |
|---|
| Gene Name | CAVIN3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 84 |
TLAQLLAKAERVSSH |
Function
Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity)
Protein Sequence
10
MRESALERGP
20
VPEAPAGGPV
30
HAVTVVTLLE
40
KLASMLETLR
50
ERQGGLARRQ
60
GGLAGSVRRI
70
QSGLGALSRS
80
HDTTSNTLAQ
90
LLAKAERVSS
100
HANAAQERAV
110
RRAAQVQRLE
120
ANHGLLVARG
130
KLHVLLFKEE
140
GEVPASAFQK
150
APEPLGPADQ
160
SELGPEQLEA
170
EVGESSDEEP
180
VESRAQRLRR
190
TGLQKVQSLR
200
RALSGRKGPA
210
APPPTPVKPP
220
RLGPGRSAEA
230
QPEAQPALEP
240
TLEPEPPQDT
250
EEDPGRPGAA
260
EEALLQMESV
A
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005901 |
caveola |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0005080 |
protein kinase C binding |
| Biological Process |
GO:0032922 |
circadian regulation of gene expression |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.