Search Results
Overview
| Uniprot ID | Q969H8 |
|---|---|
| Protein Name | Myeloid-derived growth factor |
| Gene Name | MYDGF |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 145 | TEEFEVTKTAVAHRP |
Function
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518)
Protein Sequence
10
MAAPSGGWNG
20
VGASLWAALL
30
LGAVALRPAE
40
AVSEPTTVAF
50
DVRPGGVVHS
60
FSHNVGPGDK
70
YTCMFTYASQ
80
GGTNEQWQMS
90
LGTSEDHQHF
100
TCTIWRPQGK
110
SYLYFTQFKA
120
EVRGAEIEYA
130
MAYSKAAFER
140
ESDVPLKTEE
150
FEVTKTAVAH
160
RPGAFKAELS
170
KLVIVAKASR
TEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0001938 | positive regulation of endothelial cell proliferation |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0001934 | positive regulation of protein phosphorylation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.