Search Results
Overview
| Uniprot ID | Q969J3 |
|---|---|
| Protein Name | BLOC-1-related complex subunit 5 |
| Gene Name | BORCS5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 30 | SPAKHRAKMDDIVVV |
Function
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility
Protein Sequence
10
MGSEQSSEAE
20
SRPNDLNSSV
30
TPSPAKHRAK
40
MDDIVVVAQG
50
SQASRNVSND
60
PDVIKLQEIP
70
TFQPLLKGLL
80
SGQTSPTNAK
90
LEKLDSQQVL
100
QLCLRYQDHL
110
HQCAEAVAFD
120
QNALVKRIKE
130
MDLSVETLFS
140
FMQERQKRYA
150
KYAEQIQKVN
160
EMSAILRRIQ
170
MGIDQTVPLL
180
DRLNSMLPEG
190
ERLEPFSMKP
DRELRL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0099078 | BORC complex |
| Cellular Component | GO:0098574 | cytoplasmic side of lysosomal membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Biological Process | GO:0032418 | lysosome localization |
| Biological Process | GO:0072384 | organelle transport along microtubule |
| Biological Process | GO:1903744 | positive regulation of anterograde synaptic vesicle transport |
| Biological Process | GO:0051036 | regulation of endosome size |
| Biological Process | GO:0062196 | regulation of lysosome size |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.