Overview
| Uniprot ID | Q969P0 |
|---|
| Protein Name | Immunoglobulin superfamily member 8 |
|---|
| Gene Name | IGSF8 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 113 |
QGDAVVLKIARLQAQ |
Function
Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity (PubMed:11504738, PubMed:14662754). Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities (PubMed:17785435). In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation (PubMed:22689882). Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry (PubMed:23351194). Accumulates at the presynaptic terminal, the producer cell side of the virological synapse, to prevent HIV-1 Env-mediated cell-cell fusion (PubMed:31757023). Highly expressed on malignant cells with antigen presentation defects, interacts with NK receptor KIR3DL2 to suppress NK-cell cytotoxicity (PubMed:38657602). May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain
Protein Sequence
10
MGALRPTLLP
20
PSLPLLLLLM
30
LGMGCWAREV
40
LVPEGPLYRV
50
AGTAVSISCN
60
VTGYEGPAQQ
70
NFEWFLYRPE
80
APDTALGIVS
90
TKDTQFSYAV
100
FKSRVVAGEV
110
QVQRLQGDAV
120
VLKIARLQAQ
130
DAGIYECHTP
140
STDTRYLGSY
150
SGKVELRVLP
160
DVLQVSAAPP
170
GPRGRQAPTS
180
PPRMTVHEGQ
190
ELALGCLART
200
STQKHTHLAV
210
SFGRSVPEAP
220
VGRSTLQEVV
230
GIRSDLAVEA
240
GAPYAERLAA
250
GELRLGKEGT
260
DRYRMVVGGA
270
QAGDAGTYHC
280
TAAEWIQDPD
290
GSWAQIAEKR
300
AVLAHVDVQT
310
LSSQLAVTVG
320
PGERRIGPGE
330
PLELLCNVSG
340
ALPPAGRHAA
350
YSVGWEMAPA
360
GAPGPGRLVA
370
QLDTEGVGSL
380
GPGYEGRHIA
390
MEKVASRTYR
400
LRLEAARPGD
410
AGTYRCLAKA
420
YVRGSGTRLR
430
EAASARSRPL
440
PVHVREEGVV
450
LEAVAWLAGG
460
TVYRGETASL
470
LCNISVRGGP
480
PGLRLAASWW
490
VERPEDGELS
500
SVPAQLVGGV
510
GQDGVAELGV
520
RPGGGPVSVE
530
LVGPRSHRLR
540
LHSLGPEDEG
550
VYHCAPSAWV
560
QHADYSWYQA
570
GSARSGPVTV
580
YPYMHALDTL
590
FVPLLVGTGV
600
ALVTGATVLG
610
TITCCFMKRL
RKR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0098686 |
hippocampal mossy fiber to CA3 synapse |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0042734 |
presynaptic membrane |
| Molecular Function |
GO:0038023 |
signaling receptor activity |
| Biological Process |
GO:0048870 |
cell motility |
| Biological Process |
GO:0007399 |
nervous system development |
| Biological Process |
GO:0030335 |
positive regulation of cell migration |
| Biological Process |
GO:0007338 |
single fertilization |
| Biological Process |
GO:0007519 |
skeletal muscle tissue development |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.