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Overview

Uniprot IDQ969R5
Protein NameLethal(3)malignant brain tumor-like protein 2
Gene NameL3MBTL2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
107 EAFFSKTKRFCSVSC
145 KKAKVLHKAAWSAKI
405 AHHPTFRKIYCDAVP
659 DDPQGARKISSEPVP

Function

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'

Protein Sequence

10 MEKPRSIEET 20 PSSEPMEEEE 30 DDDLELFGGY 40 DSFRSYNSSV 50 GSESSSYLEE 60 SSEAENEDRE 70 AGELPTSPLH 80 LLSPGTPRSL 90 DGSGSEPAVC 100 EMCGIVGTRE 110 AFFSKTKRFC 120 SVSCSRSYSS 130 NSKKASILAR 140 LQGKPPTKKA 150 KVLHKAAWSA 160 KIGAFLHSQG 170 TGQLADGTPT 180 GQDALVLGFD 190 WGKFLKDHSY 200 KAAPVSCFKH 210 VPLYDQWEDV 220 MKGMKVEVLN 230 SDAVLPSRVY 240 WIASVIQTAG 250 YRVLLRYEGF 260 ENDASHDFWC 270 NLGTVDVHPI 280 GWCAINSKIL 290 VPPRTIHAKF 300 TDWKGYLMKR 310 LVGSRTLPVD 320 FHIKMVESMK 330 YPFRQGMRLE 340 VVDKSQVSRT 350 RMAVVDTVIG 360 GRLRLLYEDG 370 DSDDDFWCHM 380 WSPLIHPVGW 390 SRRVGHGIKM 400 SERRSDMAHH 410 PTFRKIYCDA 420 VPYLFKKVRA 430 VYTEGGWFEE 440 GMKLEAIDPL 450 NLGNICVATV 460 CKVLLDGYLM 470 ICVDGGPSTD 480 GLDWFCYHAS 490 SHAIFPATFC 500 QKNDIELTPP 510 KGYEAQTFNW 520 ENYLEKTKSK 530 AAPSRLFNMD 540 CPNHGFKVGM 550 KLEAVDLMEP 560 RLICVATVKR 570 VVHRLLSIHF 580 DGWDSEYDQW 590 VDCESPDIYP 600 VGWCELTGYQ 610 LQPPVAAEPA 620 TPLKAKEATK 630 KKKKQFGKKR 640 KRIPPTKTRP 650 LRQGSKKPLL 660 EDDPQGARKI 670 SSEPVPGEII 680 AVRVKEEHLD 690 VASPDKASSP 700 ELPVSVENIK QETDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0140117 histone H4K20me1 reader activity
Molecular Function GO:0140005 histone H4K20me2 reader activity
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0045892 negative regulation of DNA-templated transcription

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.