Search Results
Overview
| Uniprot ID | Q969S3 |
|---|---|
| Protein Name | Cytoplasmic 60S subunit biogenesis factor ZNF622 |
| Gene Name | ZNF622 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 116 | MNEKNLEKGLGVDSV |
| 35 | HRYNLRRKVASMAPV |
Function
Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit
Protein Sequence
10
MATYTCITCR
20
VAFRDADMQR
30
AHYKTDWHRY
40
NLRRKVASMA
50
PVTAEGFQER
60
VRAQRAVAEE
70
ESKGSATYCT
80
VCSKKFASFN
90
AYENHLKSRR
100
HVELEKKAVQ
110
AVNRKVEMMN
120
EKNLEKGLGV
130
DSVDKDAMNA
140
AIQQAIKAQP
150
SMSPKKAPPA
160
PAKEARNVVA
170
VGTGGRGTHD
180
RDPSEKPPRL
190
QWFEQQAKKL
200
AKQQEEDSEE
210
EEEDLDGDDW
220
EDIDSDEELE
230
CEDTEAMDDV
240
VEQDAEEEEA
250
EEGPPLGAIP
260
ITDCLFCSHH
270
SSSLMKNVAH
280
MTKDHSFFIP
290
DIEYLSDIKG
300
LIKYLGEKVG
310
VGKICLWCNE
320
KGKSFYSTEA
330
VQAHMNDKSH
340
CKLFTDGDAA
350
LEFADFYDFR
360
SSYPDHKEGE
370
DPNKAEELPS
380
EKNLEYDDET
390
MELILPSGAR
400
VGHRSLMRYY
410
KQRFGLSRAV
420
AVAKNRKAVG
430
RVLQQYRALG
440
WTGSTGAALM
450
RERDMQYVQR
460
MKSKWMLKTG
470
MKNNATKQMH
FRVQVRF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0030687 | preribosome, large subunit precursor |
| Molecular Function | GO:1990275 | preribosome binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0046330 | positive regulation of JNK cascade |
| Biological Process | GO:0033674 | positive regulation of kinase activity |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:0042273 | ribosomal large subunit biogenesis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.