Overview
| Uniprot ID | Q969S9 |
|---|
| Protein Name | Ribosome-releasing factor 2, mitochondrial |
|---|
| Gene Name | GFM2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 83 |
MAHIDAGKTTTTERI |
Function
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with MRRF (PubMed:19716793, PubMed:33878294). Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts (PubMed:33878294). GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit (PubMed:19716793). Not involved in the GTP-dependent ribosomal translocation step during translation elongation (PubMed:19716793)
Protein Sequence
10
MLTNLRIFAM
20
SHQTIPSVYI
30
NNICCYKIRA
40
SLKRLKPHVP
50
LGRNCSSLPG
60
LIGNDIKSLH
70
SIINPPIAKI
80
RNIGIMAHID
90
AGKTTTTERI
100
LYYSGYTRSL
110
GDVDDGDTVT
120
DFMAQERERG
130
ITIQSAAVTF
140
DWKGYRVNLI
150
DTPGHVDFTL
160
EVERCLRVLD
170
GAVAVFDASA
180
GVEAQTLTVW
190
RQADKHNIPR
200
ICFLNKMDKT
210
GASFKYAVES
220
IREKLKAKPL
230
LLQLPIGEAK
240
TFKGVVDVVM
250
KEKLLWNCNS
260
NDGKDFERKP
270
LLEMNDPELL
280
KETTEARNAL
290
IEQVADLDDE
300
FADLVLEEFS
310
ENFDLLPAEK
320
LQTAIHRVTL
330
AQTAVPVLCG
340
SALKNKGIQP
350
LLDAVTMYLP
360
SPEERNYEFL
370
QWYKDDLCAL
380
AFKVLHDKQR
390
GPLVFMRIYS
400
GTIKPQLAIH
410
NINGNCTERI
420
SRLLLPFADQ
430
HVEIPSLTAG
440
NIALTVGLKH
450
TATGDTIVSS
460
KSSALAAARR
470
AEREGEKKHR
480
QNNEAERLLL
490
AGVEIPEPVF
500
FCTIEPPSLS
510
KQPDLEHALK
520
CLQREDPSLK
530
VRLDPDSGQT
540
VLCGMGELHI
550
EIIHDRIKRE
560
YGLETYLGPL
570
QVAYRETILN
580
SVRATDTLDR
590
TLGDKRHLVT
600
VEVEARPIET
610
SSVMPVIEFE
620
YAESINEGLL
630
KVSQEAIENG
640
IHSACLQGPL
650
LGSPIQDVAI
660
TLHSLTIHPG
670
TSTTMISACV
680
SRCVQKALKK
690
ADKQVLEPLM
700
NLEVTVARDY
710
LSPVLADLAQ
720
RRGNIQEIQT
730
RQDNKVVIGF
740
VPLAEIMGYS
750
TVLRTLTSGS
760
ATFALELSTY
770
QAMNPQDQNT
LLNRRSGLT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Biological Process |
GO:0032543 |
mitochondrial translation |
| Biological Process |
GO:0070126 |
mitochondrial translational termination |
| Biological Process |
GO:0032790 |
ribosome disassembly |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.