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Overview

Uniprot IDQ969T4
Protein NameUbiquitin-conjugating enzyme E2 E3
Gene NameUBE2E3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
46 KPSATQQKKNTKLSS
58 LSSKTTAKLSTSAKR

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells

Protein Sequence

10 MSSDRQRSDD 20 ESPSTSSGSS 30 DADQRDPAAP 40 EPEEQEERKP 50 SATQQKKNTK 60 LSSKTTAKLS 70 TSAKRIQKEL 80 AEITLDPPPN 90 CSAGPKGDNI 100 YEWRSTILGP 110 PGSVYEGGVF 120 FLDITFSSDY 130 PFKPPKVTFR 140 TRIYHCNINS 150 QGVICLDILK 160 DNWSPALTIS 170 KVLLSICSLL 180 TDCNPADPLV 190 GSIATQYLTN 200 RAEHDRIARQ WTKRYAT

Gene Ontology

Classification GO ID Description
Molecular Function GO:0005524 ATP binding
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0061631 ubiquitin conjugating enzyme activity
Molecular Function GO:0004842 ubiquitin-protein transferase activity
Biological Process GO:0070979 protein K11-linked ubiquitination
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0070534 protein K63-linked ubiquitination
Biological Process GO:0006513 protein monoubiquitination

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.