Search Results

Overview

Uniprot IDQ969Z3
Protein NameMitochondrial amidoxime reducing component 2
Gene NameMTARC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
156 RIFGLDIKGRDCGNE
187 VQFETNMKGRTSRKL
265 IGSVEVKKVMACPRC
69 IYPVKSCKGVPVSEA

Function

Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:21029045, PubMed:24423752). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045)

Protein Sequence

10 MGASSSSALA 20 RLGLPARPWP 30 RWLGVAALGL 40 AAVALGTVAW 50 RRAWPRRRRR 60 LQQVGTVAKL 70 WIYPVKSCKG 80 VPVSEAECTA 90 MGLRSGNLRD 100 RFWLVIKEDG 110 HMVTARQEPR 120 LVLISIIYEN 130 NCLIFRAPDM 140 DQLVLPSKQP 150 SSNKLHNCRI 160 FGLDIKGRDC 170 GNEAAKWFTN 180 FLKTEAYRLV 190 QFETNMKGRT 200 SRKLLPTLDQ 210 NFQVAYPDYC 220 PLLIMTDASL 230 VDLNTRMEKK 240 MKMENFRPNI 250 VVTGCDAFEE 260 DTWDELLIGS 270 VEVKKVMACP 280 RCILTTVDPD 290 TGVIDRKQPL 300 DTLKSYRLCD 310 PSERELYKLS 320 PLFGIYYSVE 330 KIGSLRVGDP VYRMV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0030151 molybdenum ion binding
Molecular Function GO:0043546 molybdopterin cofactor binding
Molecular Function GO:0008940 nitrate reductase activity
Molecular Function GO:0098809 nitrite reductase activity
Molecular Function GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors
Molecular Function GO:0030170 pyridoxal phosphate binding
Biological Process GO:0070458 cellular detoxification of nitrogen compound
Biological Process GO:0051410 detoxification of nitrogen compound
Biological Process GO:0042126 nitrate metabolic process
Biological Process GO:0006809 nitric oxide biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.