Search Results

Overview

Uniprot ID	Q96A00
Protein Name	Protein phosphatase 1 regulatory subunit 14A
Gene Name	PPP1R14A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
102	GLLKSCGKPVEDFIQ
13	LGKRVLSKLQSPSRA
32	GSPGGLQKRHARVTV
40	RHARVTVKYDRRELQ
98	RKIQGLLKSCGKPVE

Function

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction

Protein Sequence

10 MAAQRLGKRV 20 LSKLQSPSRA 30 RGPGGSPGGL 40 QKRHARVTVK 50 YDRRELQRRL 60 DVEKWIDGRL 70 EELYRGMEAD 80 MPDEINIDEL 90 LELESEEERS 100 RKIQGLLKSC 110 GKPVEDFIQE 120 LLAKLQGLHR 130 QPGLRQPSPS 140 HDGSLSPLQD RARTAHP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0004865	protein serine/threonine phosphatase inhibitor activity

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.