Search Results

Overview

Uniprot ID	Q96A26
Protein Name	Protein FAM162A
Gene Name	FAM162A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
139	LTSLNLEKKARLKEE
62	YNRVPLHKPTDWQKK
69	KPTDWQKKILIWSGR

Function

Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity)

Protein Sequence

10 MGSLSGLRLA 20 AGSCFRLCER 30 DVSSSLRLTR 40 SSDLKRINGF 50 CTKPQESPGA 60 PSRTYNRVPL 70 HKPTDWQKKI 80 LIWSGRFKKE 90 DEIPETVSLE 100 MLDAAKNKMR 110 VKISYLMIAL 120 TVVGCIFMVI 130 EGKKAAQRHE 140 TLTSLNLEKK 150 ARLKEEAAMK AKTE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031966	mitochondrial membrane
Cellular Component	GO:0005739	mitochondrion
Biological Process	GO:0071456	cellular response to hypoxia
Biological Process	GO:0051402	neuron apoptotic process
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.