Search Results
Overview
| Uniprot ID | Q96A49 |
|---|---|
| Protein Name | Synapse-associated protein 1 |
| Gene Name | SYAP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 71 | FASAATKKITESVAE |
Function
Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339)
Protein Sequence
10
MFRGLSSWLG
20
LQQPVAGGGQ
30
PNGDAPPEQP
40
SETVAESAEE
50
ELQQAGDQEL
60
LHQAKDFGNY
70
LFNFASAATK
80
KITESVAETA
90
QTIKKSVEEG
100
KIDGIIDKTI
110
IGDFQKEQKK
120
FVEEQHTKKS
130
EAAVPPWVDT
140
NDEETIQQQI
150
LALSADKRNF
160
LRDPPAGVQF
170
NFDFDQMYPV
180
ALVMLQEDEL
190
LSKMRFALVP
200
KLVKEEVFWR
210
NYFYRVSLIK
220
QSAQLTALAA
230
QQQAAGKEEK
240
SNGREQDLPL
250
AEAVRPKTPP
260
VVIKSQLKTQ
270
EDEEEISTSP
280
GVSEFVSDAF
290
DACNLNQEDL
300
RKEMEQLVLD
310
KKQEETAVLE
320
EDSADWEKEL
330
QQELQEYEVV
340
TESEKRDENW
350
DKEIEKMLQE
EN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0038203 | TORC2 signaling |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0045202 | synapse |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:1990314 | cellular response to insulin-like growth factor stimulus |
| Biological Process | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| Biological Process | GO:0045600 | positive regulation of fat cell differentiation |
| Biological Process | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| Biological Process | GO:0048172 | regulation of short-term neuronal synaptic plasticity |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.