Search Results

Overview

Uniprot IDQ96A65
Protein NameExocyst complex component 4
Gene NameEXOC4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
240 TNLPTPRKFLDTSHY
9 AAEAAGGKYRSTVSK

Function

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Protein Sequence

10 MAAEAAGGKY 20 RSTVSKSKDP 30 SGLLISVIRT 40 LSTSDDVEDR 50 ENEKGRLEEA 60 YEKCDRDLDE 70 LIVQHYTELT 80 TAIRTYQSIT 90 ERITNSRNKI 100 KQVKENLLSC 110 KMLLHCKRDE 120 LRKLWIEGIE 130 HKHVLNLLDE 140 IENIKQVPQK 150 LEQCMASKHY 160 LSATDMLVSA 170 VESLEGPLLQ 180 VEGLSDLRLE 190 LHSKKMNLHL 200 VLIDELHRHL 210 YIKSTSRVVQ 220 RNKEKGKISS 230 LVKDASVPLI 240 DVTNLPTPRK 250 FLDTSHYSTA 260 GSSSVREINL 270 QDIKEDLELD 280 PEENSTLFMG 290 ILIKGLAKLK 300 KIPETVKAII 310 ERLEQELKQI 320 VKRSTTQVAD 330 SGYQRGENVT 340 VENQPRLLLE 350 LLELLFDKFN 360 AVAAAHSVVL 370 GYLQDTVVTP 380 LTQQEDIKLY 390 DMADVWVKIQ 400 DVLQMLLTEY 410 LDMKNTRTAS 420 EPSAQLSYAS 430 TGREFAAFFA 440 KKKPQRPKNS 450 LFKFESSSHA 460 ISMSAYLREQ 470 RRELYSRSGE 480 LQGGPDDNLI 490 EGGGTKFVCK 500 PGARNITVIF 510 HPLLRFIQEI 520 EHALGLGPAK 530 QCPLREFLTV 540 YIKNIFLNQV 550 LAEINKEIEG 560 VTKTSDPLKI 570 LANADTMKVL 580 GVQRPLLQST 590 IIVEKTVQDL 600 LNLMHDLSAY 610 SDQFLNMVCV 620 KLQEYKDTCT 630 AAYRGIVQSE 640 EKLVISASWA 650 KDDDISRLLK 660 SLPNWMNMAQ 670 PKQLRPKREE 680 EEDFIRAAFG 690 KESEVLIGNL 700 GDKLIPPQDI 710 LRDVSDLKAL 720 ANMHESLEWL 730 ASRTKSAFSN 740 LSTSQMLSPA 750 QDSHTNTDLP 760 PVSEQIMQTL 770 SELAKSFQDM 780 ADRCLLVLHL 790 EVRVHCFHYL 800 IPLAKEGNYA 810 IVANVESMDY 820 DPLVVKLNKD 830 ISAIEEAMSA 840 SLQQHKFQYI 850 FEGLGHLISC 860 ILINGAQYFR 870 RISESGIKKM 880 CRNIFVLQQN 890 LTNITMSREA 900 DLDFARQYYE 910 MLYNTADELL 920 NLVVDQGVKY 930 TELEYIHALT 940 LLHRSQTGVG 950 ELTTQNTRLQ 960 RLKEIICEQA 970 AIKQATKDKK ITTV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0097731 9+0 non-motile cilium
Cellular Component GO:0005813 centrosome
Cellular Component GO:0097544 ciliary shaft
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000145 exocyst
Cellular Component GO:0090543 Flemming body
Cellular Component GO:0032584 growth cone membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005902 microvillus
Cellular Component GO:0035748 myelin sheath abaxonal region
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0030742 GTP-dependent protein binding
Molecular Function GO:0030165 PDZ domain binding
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0006887 exocytosis
Biological Process GO:0006893 Golgi to plasma membrane transport
Biological Process GO:0090148 membrane fission
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0015031 protein transport
Biological Process GO:0016241 regulation of macroautophagy
Biological Process GO:0006904 vesicle docking involved in exocytosis
Biological Process GO:0090522 vesicle tethering involved in exocytosis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.