Search Results
Overview
| Uniprot ID | Q96AC1 |
|---|---|
| Protein Name | Fermitin family homolog 2 |
| Gene Name | FERMT2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 581 | IARFQGGKKEELIGI |
| 582 | ARFQGGKKEELIGIA |
| 97 | LQFTPQHKLLRLQLP |
Function
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling
Protein Sequence
10
MALDGIRMPD
20
GCYADGTWEL
30
SVHVTDLNRD
40
VTLRVTGEVH
50
IGGVMLKLVE
60
KLDVKKDWSD
70
HALWWEKKRT
80
WLLKTHWTLD
90
KYGIQADAKL
100
QFTPQHKLLR
110
LQLPNMKYVK
120
VKVNFSDRVF
130
KAVSDICKTF
140
NIRHPEELSL
150
LKKPRDPTKK
160
KKKKLDDQSE
170
DEALELEGPL
180
ITPGSGSIYS
190
SPGLYSKTMT
200
PTYDAHDGSP
210
LSPTSAWFGD
220
SALSEGNPGI
230
LAVSQPITSP
240
EILAKMFKPQ
250
ALLDKAKINQ
260
GWLDSSRSLM
270
EQDVKENEAL
280
LLRFKYYSFF
290
DLNPKYDAIR
300
INQLYEQAKW
310
AILLEEIECT
320
EEEMMMFAAL
330
QYHINKLSIM
340
TSENHLNNSD
350
KEVDEVDAAL
360
SDLEITLEGG
370
KTSTILGDIT
380
SIPELADYIK
390
VFKPKKLTLK
400
GYKQYWCTFK
410
DTSISCYKSK
420
EESSGTPAHQ
430
MNLRGCEVTP
440
DVNISGQKFN
450
IKLLIPVAEG
460
MNEIWLRCDN
470
EKQYAHWMAA
480
CRLASKGKTM
490
ADSSYNLEVQ
500
NILSFLKMQH
510
LNPDPQLIPE
520
QITTDITPEC
530
LVSPRYLKKY
540
KNKQITARIL
550
EAHQNVAQMS
560
LIEAKMRFIQ
570
AWQSLPEFGI
580
THFIARFQGG
590
KKEELIGIAY
600
NRLIRMDAST
610
GDAIKTWRFS
620
NMKQWNVNWE
630
IKMVTVEFAD
640
EVRLSFICTE
650
VDCKVVHEFI
660
GGYIFLSTRA
670
KDQNESLDEE
680
MFYKLTSGWV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031258 | lamellipodium membrane |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0031674 | I band |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0043539 | protein serine/threonine kinase activator activity |
| Molecular Function | GO:0120283 | protein serine/threonine kinase binding |
| Molecular Function | GO:0046332 | SMAD binding |
| Molecular Function | GO:0034713 | type I transforming growth factor beta receptor binding |
| Biological Process | GO:0034334 | adherens junction maintenance |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0007160 | cell-matrix adhesion |
| Biological Process | GO:0048041 | focal adhesion assembly |
| Biological Process | GO:0033622 | integrin activation |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0060173 | limb development |
| Biological Process | GO:0045599 | negative regulation of fat cell differentiation |
| Biological Process | GO:0043116 | negative regulation of vascular permeability |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0051894 | positive regulation of focal adhesion assembly |
| Biological Process | GO:0033625 | positive regulation of integrin activation |
| Biological Process | GO:1902462 | positive regulation of mesenchymal stem cell proliferation |
| Biological Process | GO:0045669 | positive regulation of osteoblast differentiation |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:1900182 | positive regulation of protein localization to nucleus |
| Biological Process | GO:0035025 | positive regulation of Rho protein signal transduction |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
| Biological Process | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:1903691 | positive regulation of wound healing, spreading of epidermal cells |
| Biological Process | GO:1902414 | protein localization to cell junction |
| Biological Process | GO:0072657 | protein localization to membrane |
| Biological Process | GO:0022604 | regulation of cell morphogenesis |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0034446 | substrate adhesion-dependent cell spreading |
| Biological Process | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0016055 | Wnt signaling pathway |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.