Search Results

Overview

Uniprot IDQ96AG4
Protein NameLeucine-rich repeat-containing protein 59
Gene NameLRRC59
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
135 AGDCLDEKQCKQCAN
201 EEKERRRKEYDALKA
207 RKEYDALKAAKREQE
66 CGLTHLVKLDLSKNK
7 *MTKAGSKGGNLRDK
73 KLDLSKNKLQQLPAD

Function

Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores

Protein Sequence

10 MTKAGSKGGN 20 LRDKLDGNEL 30 DLSLSDLNEV 40 PVKELAALPK 50 ATILDLSCNK 60 LTTLPSDFCG 70 LTHLVKLDLS 80 KNKLQQLPAD 90 FGRLVNLQHL 100 DLLNNKLVTL 110 PVSFAQLKNL 120 KWLDLKDNPL 130 DPVLAKVAGD 140 CLDEKQCKQC 150 ANKVLQHMKA 160 VQADQERERQ 170 RRLEVEREAE 180 KKREAKQRAK 190 EAQERELRKR 200 EKAEEKERRR 210 KEYDALKAAK 220 REQEKKPKKE 230 ANQAPKSKSG 240 SRPRKPPPRK 250 HTRSWAVLKL 260 LLLLLLFGVA 270 GGLVACRVTE 280 LQQQPLCTSV 290 NTIYDNAVQG 300 LRRHEILQWV LQTDSQQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0042645 mitochondrial nucleoid
Cellular Component GO:0005635 nuclear envelope
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0035556 intracellular signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.