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Overview

Uniprot IDQ96B23
Protein NameProtein ARK2N
Gene NameARK2N
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
358 IQSVSSWKHGSGTQY

Function

AMPK substrate important for exercise capacity and skeletal muscle function. Required for normal contraction-induced signaling

Protein Sequence

10 MKMEEAVGKV 20 EELIESEAPP 30 KASEQETAKE 40 EDGSVELESQ 50 VQKDGVADST 60 VISSMPCLLM 70 ELRRDSSESQ 80 LASTESDKPT 90 TGRVYESDSS 100 NHCMLSPSSS 110 GHLADSDTLS 120 SAEENEPSQA 130 ETAVEGDPSG 140 VSGATVGRKS 150 RRSRSESETS 160 TMAAKKNRQS 170 SDKQNGRVAK 180 VKGHRSQKHK 190 ERIRLLRQKR 200 EAAARKKYNL 210 LQDSSTSDSD 220 LTCDSSTSSS 230 DDDEEVSGSS 240 KTITAEIPDG 250 PPVVAHYDMS 260 DTNSDPEVVN 270 VDNLLAAAVV 280 QEHSNSVGGQ 290 DTGATWRTSG 300 LLEELNAEAG 310 HLDPGFLASD 320 KTSAGNAPLN 330 EEINIASSDS 340 EVEIVGVQEH 350 ARCVHPRGGV 360 IQSVSSWKHG 370 SGTQYVSTRQ 380 TQSWTAVTPQ 390 QTWASPAEVV 400 DLTLDEDSRR KYLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0061630 ubiquitin protein ligase activity
Biological Process GO:1903901 negative regulation of viral life cycle
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.