Overview
| Uniprot ID | Q96B36 |
|---|
| Protein Name | Proline-rich AKT1 substrate 1 |
|---|
| Gene Name | AKT1S1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 251 |
LNTSDFQKLKRKY** |
Function
Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17277771, PubMed:17386266, PubMed:17510057, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity)
Protein Sequence
10
MASGRPEELW
20
EAVVGAAERF
30
RARTGTELVL
40
LTAAPPPPPR
50
PGPCAYAAHG
60
RGALAEAARR
70
CLHDIALAHR
80
AATAARPPAP
90
PPAPQPPSPT
100
PSPPRPTLAR
110
EDNEEDEDEP
120
TETETSGEQL
130
GISDNGGLFV
140
MDEDATLQDL
150
PPFCESDPES
160
TDDGSLSEET
170
PAGPPTCSVP
180
PASALPTQQY
190
AKSLPVSVPV
200
WGFKEKRTEA
210
RSSDEENGPP
220
SSPDLDRIAA
230
SMRALVLREA
240
EDTQVFGDLP
250
RPRLNTSDFQ
KLKRKY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0031931 |
TORC1 complex |
| Molecular Function |
GO:0004860 |
protein kinase inhibitor activity |
| Molecular Function |
GO:0030291 |
protein serine/threonine kinase inhibitor activity |
| Biological Process |
GO:0045792 |
negative regulation of cell size |
| Biological Process |
GO:0006469 |
negative regulation of protein kinase activity |
| Biological Process |
GO:0032007 |
negative regulation of TOR signaling |
| Biological Process |
GO:1904262 |
negative regulation of TORC1 signaling |
| Biological Process |
GO:0048011 |
neurotrophin TRK receptor signaling pathway |
| Biological Process |
GO:0042981 |
regulation of apoptotic process |
| Biological Process |
GO:0043523 |
regulation of neuron apoptotic process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.