Search Results

Overview

Uniprot IDQ96B97
Protein NameSH3 domain-containing kinase-binding protein 1
Gene NameSH3KBP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
211 AIQPKKVKGVGFGDI
220 VGFGDIFKDKPIKLR
247 VEKTIGKKLPATTAT
535 DASKKTSKTVTISQV

Function

Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373)

Protein Sequence

10 MVEAIVEFDY 20 QAQHDDELTI 30 SVGEIITNIR 40 KEDGGWWEGQ 50 INGRRGLFPD 60 NFVREIKKEM 70 KKDPLTNKAP 80 EKPLHEVPSG 90 NSLLSSETIL 100 RTNKRGERRR 110 RRCQVAFSYL 120 PQNDDELELK 130 VGDIIEVVGE 140 VEEGWWEGVL 150 NGKTGMFPSN 160 FIKELSGESD 170 ELGISQDEQL 180 SKSSLRETTG 190 SESDGGDSSS 200 TKSEGANGTV 210 ATAAIQPKKV 220 KGVGFGDIFK 230 DKPIKLRPRS 240 IEVENDFLPV 250 EKTIGKKLPA 260 TTATPDSSKT 270 EMDSRTKSKD 280 YCKVIFPYEA 290 QNDDELTIKE 300 GDIVTLINKD 310 CIDVGWWEGE 320 LNGRRGVFPD 330 NFVKLLPPDF 340 EKEGNRPKKP 350 PPPSAPVIKQ 360 GAGTTERKHE 370 IKKIPPERPE 380 MLPNRTEEKE 390 RPEREPKLDL 400 QKPSVPAIPP 410 KKPRPPKTNS 420 LSRPGALPPR 430 RPERPVGPLT 440 HTRGDSPKID 450 LAGSSLSGIL 460 DKDLSDRSND 470 IDLEGFDSVV 480 SSTEKLSHPT 490 TSRPKATGRR 500 PPSQSLTSSS 510 LSSPDIFDSP 520 SPEEDKEEHI 530 SLAHRGVDAS 540 KKTSKTVTIS 550 QVSDNKASLP 560 PKPGTMAAGG 570 GGPAPLSSAA 580 PSPLSSSLGT 590 AGHRANSPSL 600 FGTEGKPKME 610 PAASSQAAVE 620 ELRTQVRELR 630 SIIETMKDQQ 640 KREIKQLLSE 650 LDEEKKIRLR 660 LQMEVNDIKK ALQSK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030659 cytoplasmic vesicle membrane
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0098982 GABA-ergic synapse
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0014069 postsynaptic density
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0017124 SH3 domain binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0006915 apoptotic process
Biological Process GO:0016477 cell migration
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0006897 endocytosis
Biological Process GO:0050871 positive regulation of B cell activation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.