Search Results

Overview

Uniprot ID	Q96BD5
Protein Name	PHD finger protein 21A
Gene Name	PHF21A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
25	QKLVAQMKQDPQNAD
520	DCLDPPLKTIPKGMW
596	QLSNSISKCMEMKNT

Function

Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation

Protein Sequence

10 MELQTLQEAL 20 KVEIQVHQKL 30 VAQMKQDPQN 40 ADLKKQLHEL 50 QAKITALSEK 60 QKRVVEQLRK 70 NLIVKQEQPD 80 KFQIQPLPQS 90 ENKLQTAQQQ 100 PLQQLQQQQQ 110 YHHHHAQQSA 120 AASPNLTASQ 130 KTVTTASMIT 140 TKTLPLVLKA 150 ATATMPASVV 160 GQRPTIAMVT 170 AINSQKAVLS 180 TDVQNTPVNL 190 QTSSKVTGPG 200 AEAVQIVAKN 210 TVTLVQATPP 220 QPIKVPQFIP 230 PPRLTPRPNF 240 LPQVRPKPVA 250 QNNIPIAPAP 260 PPMLAAPQLI 270 QRPVMLTKFT 280 PTTLPTSQNS 290 IHPVRVVNGQ 300 TATIAKTFPM 310 AQLTSIVIAT 320 PGTRLAGPQT 330 VQLSKPSLEK 340 QTVKSHTETD 350 EKQTESRTIT 360 PPAAPKPKRE 370 ENPQKLAFMV 380 SLGLVTHDHL 390 EEIQSKRQER 400 KRRTTANPVY 410 SGAVFEPERK 420 KSAVTYLNST 430 MHPGTRKRGR 440 PPKYNAVLGF 450 GALTPTSPQS 460 SHPDSPENEK 470 TETTFTFPAP 480 VQPVSLPSPT 490 STDGDIHEDF 500 CSVCRKSGQL 510 LMCDTCSRVY 520 HLDCLDPPLK 530 TIPKGMWICP 540 RCQDQMLKKE 550 EAIPWPGTLA 560 IVHSYIAYKA 570 AKEEEKQKLL 580 KWSSDLKQER 590 EQLEQKVKQL 600 SNSISKCMEM 610 KNTILARQKE 620 MHSSLEKVKQ 630 LIRLIHGIDL 640 SKPVDSEATV 650 GAISNGPDCT 660 PPANAATSTP 670 APSPSSQSCT 680 ANCNQGEETK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:1990391	DNA repair complex
Cellular Component	GO:0000118	histone deacetylase complex
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.