Search Results
Overview
| Uniprot ID | Q96BK5 |
|---|---|
| Protein Name | PIN2/TERF1-interacting telomerase inhibitor 1 |
| Gene Name | PINX1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | FSLEEKSKISKNRVH |
| 149 | DLDCIFGKRQSKKTP |
| 190 | AKRMAALKNKPQVPV |
| 253 | QERVAKKKSAPAEEQ |
| 301 | KKRRGKKKLQKPVEI |
| 36 | FGQRMLEKMGWSKGK |
| 43 | KMGWSKGKGLGAQEQ |
Function
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor
Protein Sequence
10
MSMLAERRRK
20
QKWAVDPQNT
30
AWSNDDSKFG
40
QRMLEKMGWS
50
KGKGLGAQEQ
60
GATDHIKVQV
70
KNNHLGLGAT
80
INNEDNWIAH
90
QDDFNQLLAE
100
LNTCHGQETT
110
DSSDKKEKKS
120
FSLEEKSKIS
130
KNRVHYMKFT
140
KGKDLSSRSK
150
TDLDCIFGKR
160
QSKKTPEGDA
170
SPSTPEENET
180
TTTSAFTIQE
190
YFAKRMAALK
200
NKPQVPVPGS
210
DISETQVERK
220
RGKKRNKEAT
230
GKDVESYLQP
240
KAKRHTEGKP
250
ERAEAQERVA
260
KKKSAPAEEQ
270
LRGPCWDQSS
280
KASAQDAGDH
290
VQPPEGRDFT
300
LKPKKRRGKK
310
KLQKPVEIAE
320
DATLEETLVK
KKKKKDSK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0000228 | nuclear chromosome |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0010521 | telomerase inhibitor activity |
| Molecular Function | GO:0070034 | telomerase RNA binding |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle |
| Biological Process | GO:0031397 | negative regulation of protein ubiquitination |
| Biological Process | GO:0032211 | negative regulation of telomere maintenance via telomerase |
| Biological Process | GO:1904357 | negative regulation of telomere maintenance via telomere lengthening |
| Biological Process | GO:1904751 | positive regulation of protein localization to nucleolus |
| Biological Process | GO:0070198 | protein localization to chromosome, telomeric region |
| Biological Process | GO:1902570 | protein localization to nucleolus |
| Biological Process | GO:0031647 | regulation of protein stability |
| Biological Process | GO:0007004 | telomere maintenance via telomerase |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.