Search Results

Overview

Uniprot IDQ96BP3
Protein NamePeptidylprolyl isomerase domain and WD repeat-containing protein 1
Gene NamePPWD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
62 PVEATLAKKRKVLEF
63 VEATLAKKRKVLEFE
65 ATLAKKRKVLEFERV

Function

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638)

Protein Sequence

10 MAAESGSDFQ 20 QRRRRRRDPE 30 EPEKTELSER 40 ELAVAVAVSQ 50 ENDEENEERW 60 VGPLPVEATL 70 AKKRKVLEFE 80 RVYLDNLPSA 90 SMYERSYMHR 100 DVITHVVCTK 110 TDFIITASHD 120 GHVKFWKKIE 130 EGIEFVKHFR 140 SHLGVIESIA 150 VSSEGALFCS 160 VGDDKAMKVF 170 DVVNFDMINM 180 LKLGYFPGQC 190 EWIYCPGDAI 200 SSVAASEKST 210 GKIFIYDGRG 220 DNQPLHIFDK 230 LHTSPLTQIR 240 LNPVYKAVVS 250 SDKSGMIEYW 260 TGPPHEYKFP 270 KNVNWEYKTD 280 TDLYEFAKCK 290 AYPTSVCFSP 300 DGKKIATIGS 310 DRKVRIFRFV 320 TGKLMRVFDE 330 SLSMFTELQQ 340 MRQQLPDMEF 350 GRRMAVEREL 360 EKVDAVRLIN 370 IVFDETGHFV 380 LYGTMLGIKV 390 INVETNRCVR 400 ILGKQENIRV 410 MQLALFQGIA 420 KKHRAATTIE 430 MKASENPVLQ 440 NIQADPTIVC 450 TSFKKNRFYM 460 FTKREPEDTK 470 SADSDRDVFN 480 EKPSKEEVMA 490 ATQAEGPKRV 500 SDSAIIHTSM 510 GDIHTKLFPV 520 ECPKTVENFC 530 VHSRNGYYNG 540 HTFHRIIKGF 550 MIQTGDPTGT 560 GMGGESIWGG 570 EFEDEFHSTL 580 RHDRPYTLSM 590 ANAGSNTNGS 600 QFFITVVPTP 610 WLDNKHTVFG 620 RVTKGMEVVQ 630 RISNVKVNPK 640 TDKPYEDVSI INITVK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003755 peptidyl-prolyl cis-trans isomerase activity
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.