Search Results

Overview

Uniprot IDQ96BY7
Protein NameAutophagy-related protein 2 homolog B
Gene NameATG2B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1669 FLYLYCSKEMPRKAH

Function

Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365)

Protein Sequence

10 MPWPFSESIK 20 KRACRYLLQR 30 YLGHFLQEKL 40 SLEQLSLDLY 50 QGTGSLAQVP 60 LDKWCLNEIL 70 ESADAPLEVT 80 EGFIQSISLS 90 VPWGSLLQDN 100 CALEVRGLEM 110 VFRPRPRPAT 120 GSEPMYWSSF 130 MTSSMQLAKE 140 CLSQKLTDEQ 150 GEGSQPFEGL 160 EKFAETIETV 170 LRRVKVTFID 180 TVLRIEHVPE 190 NSKTGTALEI 200 RIERTVYCDE 210 TADESSGINV 220 HQPTAFAHKL 230 LQLSGVSLFW 240 DEFSASAKSS 250 PVCSTAPVET 260 EPKLSPSWNP 270 KIIYEPHPQL 280 TRNLPEIAPS 290 DPVQIGRLIG 300 RLELSLTLKQ 310 NEVLPGAKLD 320 VDGQIDSIHL 330 LLSPRQVHLL 340 LDMLAAIAGP 350 ENSSKIGLAN 360 KDRKNRPMQQ 370 EDEYRIQMEL 380 NRYYLRKDSL 390 SVGVSSEQSF 400 YETETARTPS 410 SREEEVFFSM 420 ADMDMSHSLS 430 SLPPLGDPPN 440 MDLELSLTST 450 YTNTPAGSPL 460 SATVLQPTWG 470 EFLDHHKEQP 480 VRGSTFPSNL 490 VHPTPLQKTS 500 LPSRSVSVDE 510 SRPELIFRLA 520 VGTFSISVLH 530 IDPLSPPETS 540 QNLNPLTPMA 550 VAFFTCIEKI 560 DPARFSTEDF 570 KSFRAVFAEA 580 CSHDHLRFIG 590 TGIKVSYEQR 600 QRSASRYFST 610 DMSIGQMEFL 620 ECLFPTDFHS 630 VPPHYTELLT 640 FHSKEETGSH 650 SPVCLQLHYK 660 HSENRGPQGN 670 QARLSSVPHK 680 AELQIKLNPV 690 CCELDISIVD 700 RLNSLLQPQK 710 LATVEMMASH 720 MYTSYNKHIS 730 LHKAFTEVFL 740 DDSHSPANCR 750 ISVQVATPAL 760 NLSVRFPIPD 770 LRSDQERGPW 780 FKKSLQKEIL 790 YLAFTDLEFK 800 TEFIGGSTPE 810 QIKLELTFRE 820 LIGSFQEEKG 830 DPSIKFFHVS 840 SGVDGDTTSS 850 DDFDWPRIVL 860 KINPPAMHSI 870 LERIAAEEEE 880 ENDGHYQEEE 890 EGGAHSLKDV 900 CDLRRPAPSP 910 FSSRRVMFEN 920 EQMVMPGDPV 930 EMTEFQDKAI 940 SNSHYVLELT 950 LPNIYVTLPN 960 KSFYEKLYNR 970 IFNDLLLWEP 980 TAPSPVETFE 990 NISYGIGLSV 1000 ASQLINTFNK 1010 DSFSAFKSAV 1020 HYDEESGSEE 1030 ETLQYFSTVD 1040 PNYRSRRKKK 1050 LDSQNKNSQS 1060 FLSVLLNINH 1070 GLIAVFTDVK 1080 QDNGDLLENK 1090 HGEFWLEFNS 1100 GSLFCVTKYE 1110 GFDDKHYICL 1120 HSSSFSLYHK 1130 GIVNGVILPT 1140 ETRLPSSTRP 1150 HWLEPTIYSS 1160 EEDGLSKTSS 1170 DGVGGDSLNM 1180 LSVAVKILSD 1190 KSESNTKEFL 1200 IAVGLKGATL 1210 QHRMLPSGLS 1220 WHEQILYFLN 1230 IADEPVLGYN 1240 PPTSFTTFHV 1250 HLWSCALDYR 1260 PLYLPIRSLL 1270 TVETFSVSSS 1280 VALDKSSSTL 1290 RIILDEAALH 1300 LSDKCNTVTI 1310 NLSRDYVRVM 1320 DMGLLELTIT 1330 AVKSDSDGEQ 1340 TEPRFELHCS 1350 SDVVHIRTCS 1360 DSCAALMNLI 1370 QYIASYGDLQ 1380 TPNKADMKPG 1390 AFQRRSKVDS 1400 SGRSSSRGPV 1410 LPEADQQMLR 1420 DLMSDAMEEI 1430 DMQQGTSSVK 1440 PQANGVLDEK 1450 SQIQEPCCSD 1460 LFLFPDESGN 1470 VSQESGPTYA 1480 SFSHHFISDA 1490 MTGVPTENDD 1500 FCILFAPKAA 1510 MQEKEEEPVI 1520 KIMVDDAIVI 1530 RDNYFSLPVN 1540 KTDTSKAPLH 1550 FPIPVIRYVV 1560 KEVSLVWHLY 1570 GGKDFGIVPP 1580 TSPAKSYISP 1590 HSSPSHTPTR 1600 HGRNTVCGGK 1610 GRNHDFLMEI 1620 QLSKVKFQHE 1630 VYPPCKPDCD 1640 SSLSEHPVSR 1650 QVFIVQDLEI 1660 RDRLATSQMN 1670 KFLYLYCSKE 1680 MPRKAHSNML 1690 TVKALHVCPE 1700 SGRSPQECCL 1710 RVSLMPLRLN 1720 IDQDALFFLK 1730 DFFTSLSAEV 1740 ELQMTPDPEV 1750 KKSPGADVTC 1760 SLPRHLSTSK 1770 EPNLVISFSG 1780 PKQPSQNDSA 1790 NSVEVVNGME 1800 EKNFSAEEAS 1810 FRDQPVFFRE 1820 FRFTSEVPIR 1830 LDYHGKHVSM 1840 DQGTLAGILI 1850 GLAQLNCSEL 1860 KLKRLSYRHG 1870 LLGVDKLFSY 1880 AITEWLNDIK 1890 KNQLPGILGG 1900 VGPMHSLVQL 1910 VQGLKDLVWL 1920 PIEQYRKDGR 1930 IVRGFQRGAA 1940 SFGTSTAMAA 1950 LELTNRMVQT 1960 IQAAAETAYD 1970 MVSPGTLSIE 1980 PKKTKRFPHH 1990 RLAHQPVDLR 2000 EGVAKAYSVV 2010 KEGITDTAQT 2020 IYETAAREHE 2030 SRGVTGAVGE 2040 VLRQIPPAVV 2050 KPLIVATEAT 2060 SNVLGGMRNQ 2070 IRPDVRQDES QKWRHGDD

Gene Ontology

Classification GO ID Description
Molecular Function GO:0120013 lipid transfer activity
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005811 lipid droplet
Cellular Component GO:0061908 phagophore
Cellular Component GO:0000407 phagophore assembly site
Cellular Component GO:0034045 phagophore assembly site membrane
Molecular Function GO:0032266 phosphatidylinositol-3-phosphate binding
Molecular Function GO:0043495 protein-membrane adaptor activity
Biological Process GO:0000045 autophagosome assembly
Biological Process GO:0000422 autophagy of mitochondrion
Biological Process GO:0061723 glycophagy
Biological Process GO:0000425 pexophagy
Biological Process GO:0034727 piecemeal microautophagy of the nucleus
Biological Process GO:0061709 reticulophagy

Reference

PMID: N/A