Search Results

Overview

Uniprot IDQ96C19
Protein NameEF-hand domain-containing protein D2
Gene NameEFHD2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
188 DVSSEGVKGAKSFFE
191 SEGVKGAKSFFEAKV
197 AKSFFEAKVQAINVS
233 KQRKAAFKELQSTFK
240 KELQSTFK*******
9 ATDELATKLSRRLQM

Function

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance

Protein Sequence

10 MATDELATKL 20 SRRLQMEGEG 30 GGETPEQPGL 40 NGAAAAAAGA 50 PDEAAEALGS 60 ADCELSAKLL 70 RRADLNQGIG 80 EPQSPSRRVF 90 NPYTEFKEFS 100 RKQIKDMEKM 110 FKQYDAGRDG 120 FIDLMELKLM 130 MEKLGAPQTH 140 LGLKNMIKEV 150 DEDFDSKLSF 160 REFLLIFRKA 170 AAGELQEDSG 180 LCVLARLSEI 190 DVSSEGVKGA 200 KSFFEAKVQA 210 INVSSRFEEE 220 IKAEQEERKK 230 QAEEMKQRKA 240 AFKELQSTFK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0045121 membrane raft
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0061891 calcium ion sensor activity
Biological Process GO:0051764 actin crosslink formation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.