Search Results

Overview

Uniprot IDQ96C23
Protein NameGalactose mutarotase
Gene NameGALM
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
101 EYHLAINKEPNSLHG
254 CLKGSKEKHFCARVH
93 GTFKVDGKEYHLAIN

Function

Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism (PubMed:12753898). Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase) (PubMed:30451973). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1 (PubMed:12753898). Also active on D-glucose although shows a preference for galactose over glucose (PubMed:12753898)

Protein Sequence

10 MASVTRAVFG 20 ELPSGGGTVE 30 KFQLQSDLLR 40 VDIISWGCTI 50 TALEVKDRQG 60 RASDVVLGFA 70 ELEGYLQKQP 80 YFGAVIGRVA 90 NRIAKGTFKV 100 DGKEYHLAIN 110 KEPNSLHGGV 120 RGFDKVLWTP 130 RVLSNGVQFS 140 RISPDGEEGY 150 PGELKVWVTY 160 TLDGGELIVN 170 YRAQASQATP 180 VNLTNHSYFN 190 LAGQASPNIN 200 DHEVTIEADT 210 YLPVDETLIP 220 TGEVAPVQGT 230 AFDLRKPVEL 240 GKHLQDFHLN 250 GFDHNFCLKG 260 SKEKHFCARV 270 HHAASGRVLE 280 VYTTQPGVQF 290 YTGNFLDGTL 300 KGKNGAVYPK 310 HSGFCLETQN 320 WPDAVNQPRF 330 PPVLLRPGEE 340 YDHTTWFKFS VA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0004034 aldose 1-epimerase activity
Molecular Function GO:0030246 carbohydrate binding
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway
Biological Process GO:0006012 galactose metabolic process
Biological Process GO:0006006 glucose metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.