Search Results
Overview
| Uniprot ID | Q96C24 |
|---|---|
| Protein Name | Synaptotagmin-like protein 4 |
| Gene Name | SYTL4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 666 | QLRSSMAKQKLGL** |
Function
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity)
Protein Sequence
10
MSELLDLSFL
20
SEEEKDLILS
30
VLQRDEEVRK
40
ADEKRIRRLK
50
NELLEIKRKG
60
AKRGSQHYSD
70
RTCARCQESL
80
GRLSPKTNTC
90
RGCNHLVCRD
100
CRIQESNGTW
110
RCKVCAKEIE
120
LKKATGDWFY
130
DQKVNRFAYR
140
TGSEIIRMSL
150
RHKPAVSKRE
160
TVGQSLLHQT
170
QMGDIWPGRK
180
IIQERQKEPS
190
VLFEVPKLKS
200
GKSALEAESE
210
SLDSFTADSD
220
STSRRDSLDK
230
SGLFPEWKKM
240
SAPKSQVEKE
250
TQPGGQNVVF
260
VDEGEMIFKK
270
NTRKILRPSE
280
YTKSVIDLRP
290
EDVVHESGSL
300
GDRSKSVPGL
310
NVDMEEEEEE
320
EDIDHLVKLH
330
RQKLARSSMQ
340
SGSSMSTIGS
350
MMSIYSEAGD
360
FGNIFVTGRI
370
AFSLKYEQQT
380
QSLVVHVKEC
390
HQLAYADEAK
400
KRSNPYVKTY
410
LLPDKSRQGK
420
RKTSIKRDTI
430
NPLYDETLRY
440
EIPESLLAQR
450
TLQFSVWHHG
460
RFGRNTFLGE
470
AEIQMDSWKL
480
DKKLDHCLPL
490
HGKISAESPT
500
GLPSHKGELV
510
VSLKYIPASK
520
TPVGGDRKKS
530
KGGEGGELQV
540
WIKEAKNLTA
550
AKAGGTSDSF
560
VKGYLLPMRN
570
KASKRKTPVM
580
KKTLNPHYNH
590
TFVYNGVRLE
600
DLQHMCLELT
610
VWDREPLASN
620
DFLGGVRLGV
630
GTGISNGEVV
640
DWMDSTGEEV
650
SLWQKMRQYP
660
GSWAEGTLQL
670
RSSMAKQKLG
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070382 | exocytic vesicle |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0031092 | platelet alpha granule membrane |
| Cellular Component | GO:0030658 | transport vesicle membrane |
| Molecular Function | GO:0042043 | neurexin family protein binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006887 | exocytosis |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0032418 | lysosome localization |
| Biological Process | GO:0071985 | multivesicular body sorting pathway |
| Biological Process | GO:0001778 | plasma membrane repair |
| Biological Process | GO:0045921 | positive regulation of exocytosis |
| Biological Process | GO:0050714 | positive regulation of protein secretion |
| Biological Process | GO:1905684 | regulation of plasma membrane repair |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.