Overview
| Uniprot ID | Q96C36 |
|---|
| Protein Name | Pyrroline-5-carboxylate reductase 2 |
|---|
| Gene Name | PYCR2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 284 |
ISPAALKKTLLDRVK |
Function
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:23024808, PubMed:2722838, PubMed:6894153). At physiologic concentrations, has higher specific activity in the presence of NADH (PubMed:23024808, PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492). In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+) (PubMed:2722838, PubMed:6894153)
Protein Sequence
10
MSVGFIGAGQ
20
LAYALARGFT
30
AAGILSAHKI
40
IASSPEMNLP
50
TVSALRKMGV
60
NLTRSNKETV
70
KHSDVLFLAV
80
KPHIIPFILD
90
EIGADVQARH
100
IVVSCAAGVT
110
ISSVEKKLMA
120
FQPAPKVIRC
130
MTNTPVVVQE
140
GATVYATGTH
150
ALVEDGQLLE
160
QLMSSVGFCT
170
EVEEDLIDAV
180
TGLSGSGPAY
190
AFMALDALAD
200
GGVKMGLPRR
210
LAIQLGAQAL
220
LGAAKMLLDS
230
EQHPCQLKDN
240
VCSPGGATIH
250
ALHFLESGGF
260
RSLLINAVEA
270
SCIRTRELQS
280
MADQEKISPA
290
ALKKTLLDRV
300
KLESPTVSTL
310
TPSSPGKLLT
320
RSLALGGKKD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0004735 |
pyrroline-5-carboxylate reductase activity |
| Biological Process |
GO:0034599 |
cellular response to oxidative stress |
| Biological Process |
GO:0055129 |
L-proline biosynthetic process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.