Search Results

Overview

Uniprot ID	Q96C90
Protein Name	Protein phosphatase 1 regulatory subunit 14B
Gene Name	PPP1R14B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
140	DKIRGMQKLSTPQKK
146	QKLSTPQKK******
147	KLSTPQKK*******
55	GPVRRQGKVTVKYDR
59	RQGKVTVKYDRKELR

Function

Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity)

Protein Sequence

10 MADSGTAGGA 20 ALAAPAPGPG 30 SGGPGPRVYF 40 QSPPGAAGEG 50 PGGADDEGPV 60 RRQGKVTVKY 70 DRKELRKRLN 80 LEEWILEQLT 90 RLYDCQEEEI 100 PELEIDVDEL 110 LDMESDDARA 120 ARVKELLVDC 130 YKPTEAFISG 140 LLDKIRGMQK LSTPQKK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0004865	protein serine/threonine phosphatase inhibitor activity
Biological Process	GO:0045087	innate immune response

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.