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Overview

Uniprot IDQ96CB8
Protein NameIntegrator complex subunit 12
Gene NameINTS12
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
229 KTQKPPQKPAPAVVS
329 ATSSANQKPVGLTGL
341 TGLATSSKGGIGSKI
446 ESQLNAMKRLQMVKK
63 PPKISSTKNISIKQE

Function

Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267)

Protein Sequence

10 MAATVNLELD 20 PIFLKALGFL 30 HSKSKDSAEK 40 LKALLDESLA 50 RGIDSSYRPS 60 QKDVEPPKIS 70 STKNISIKQE 80 PKISSSLPSG 90 NNNGKVLTTE 100 KVKKEAEKRP 110 ADKMKSDITE 120 GVDIPKKPRL 130 EKPETQSSPI 140 TVQSSKDLPM 150 ADLSSFEETS 160 ADDFAMEMGL 170 ACVVCRQMMV 180 ASGNQLVECQ 190 ECHNLYHRDC 200 HKPQVTDKEA 210 NDPRLVWYCA 220 RCTRQMKRMA 230 QKTQKPPQKP 240 APAVVSVTPA 250 VKDPLVKKPE 260 TKLKQETTFL 270 AFKRTEVKTS 280 TVISGNSSSA 290 SVSSSVTSGL 300 TGWAAFAAKT 310 SSAGPSTAKL 320 SSTTQNNTGK 330 PATSSANQKP 340 VGLTGLATSS 350 KGGIGSKIGS 360 NNSTTPTVPL 370 KPPPPLTLGK 380 TGLSRSVSCD 390 NVSKVGLPSP 400 SSLVPGSSSQ 410 LSGNGNSGTS 420 GPSGSTTSKT 430 TSESSSSPSA 440 SLKGPTSQES 450 QLNAMKRLQM 460 VKKKAAQKKL KK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0160232 INTAC complex
Cellular Component GO:0032039 integrator complex
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0034243 regulation of transcription elongation by RNA polymerase II
Biological Process GO:0160240 RNA polymerase II transcription initiation surveillance
Biological Process GO:0034472 snRNA 3'-end processing
Biological Process GO:0016180 snRNA processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.