Search Results
Overview
| Uniprot ID | Q96CJ1 |
|---|---|
| Protein Name | ELL-associated factor 2 |
| Gene Name | EAF2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 119 | TRVEGSSKIQYRKEQ |
Function
Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo
Protein Sequence
10
MNSAAGFSHL
20
DRRERVLKLG
30
ESFEKQPRCA
40
FHTVRYDFKP
50
ASIDTSSEGY
60
LEVGEGEQVT
70
ITLPNIEGST
80
PPVTVFKGSK
90
KPYLKECILI
100
INHDTGECRL
110
EKLSSNITVK
120
KTRVEGSSKI
130
QYRKEQQQQQ
140
MWNSARTPNL
150
VKHSPSEDKM
160
SPASPIDDIE
170
RELKAEASLM
180
DQMSSCDSSS
190
DSKSSSSSSS
200
EDSSSDSEDE
210
DCKSSTSDTG
220
NCVSGHPTMT
230
QYRIPDIDAS
240
HNRFRDNSGL
250
LMNTLRNDLQ
260
LSESGSDSDD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0032783 | super elongation complex |
| Cellular Component | GO:0008023 | transcription elongation factor complex |
| Molecular Function | GO:0003711 | transcription elongation factor activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0034243 | regulation of transcription elongation by RNA polymerase II |
| Biological Process | GO:0006368 | transcription elongation by RNA polymerase II |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.