Search Results

Overview

Uniprot ID	Q96CN7
Protein Name	Isochorismatase domain-containing protein 1
Gene Name	ISOC1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
279	DKDHPKFKEIQNLIK

Function

No function data available.

Protein Sequence

10 MAAAEPAVLA 20 LPNSGAGGAG 30 APSGTVPVLF 40 CFSVFARPSS 50 VPHGAGYELL 60 IQKFLSLYGD 70 QIDMHRKFVV 80 QLFAEEWGQY 90 VDLPKGFAVS 100 ERCKVRLVPL 110 QIQLTTLGNL 120 TPSSTVFFCC 130 DMQERFRPAI 140 KYFGDIISVG 150 QRLLQGARIL 160 GIPVIVTEQY 170 PKGLGSTVQE 180 IDLTGVKLVL 190 PKTKFSMVLP 200 EVEAALAEIP 210 GVRSVVLFGV 220 ETHVCIQQTA 230 LELVGRGVEV 240 HIVADATSSR 250 SMMDRMFALE 260 RLARTGIIVT 270 TSEAVLLQLV 280 ADKDHPKFKE 290 IQNLIKASAP ESGLLSKV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005777	peroxisome

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.