Search Results

Overview

Uniprot ID	Q96CP2
Protein Name	FLYWCH family member 2
Gene Name	FLYWCH2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
101	APQEPEQKRSRQDPG
41	RKPRKFSKLVLLTAS
49	LVLLTASKDSTKVAG
53	TASKDSTKVAGAKRK

Function

No function data available.

Protein Sequence

10 MPLPEPSEQE 20 GESVKASQEP 30 SPKPGTEVIP 40 AAPRKPRKFS 50 KLVLLTASKD 60 STKVAGAKRK 70 GVHCVMSLGV 80 PGPATLAKAL 90 LQTHPEAQRA 100 IEAAPQEPEQ 110 KRSRQDPGTD 120 RTEDSGLAAG 130 PPEAAGENFA 140 PCSVAPGKSL

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0003723	RNA binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.