Overview
| Uniprot ID | Q96CQ1 |
|---|
| Protein Name | Solute carrier family 25 member 36 |
|---|
| Gene Name | SLC25A36 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 237 |
MLAAATSKTCATTIA |
Function
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports cytosine, guanosine, inosine and uridine (deoxy)nucleoside mono-, di-, and triphosphates by antiport mechanism. Catalyzes uniport at much lower rate (PubMed:25320081). May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside mono- and diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration
Protein Sequence
10
MSQRDTLVHL
20
FAGGCGGTVG
30
AILTCPLEVV
40
KTRLQSSSVT
50
LYISEVQLNT
60
MAGASVNRVV
70
SPGPLHCLKV
80
ILEKEGPRSL
90
FRGLGPNLVG
100
VAPSRAIYFA
110
AYSNCKEKLN
120
DVFDPDSTQV
130
HMISAAMAGF
140
TAITATNPIW
150
LIKTRLQLDA
160
RNRGERRMGA
170
FECVRKVYQT
180
DGLKGFYRGM
190
SASYAGISET
200
VIHFVIYESI
210
KQKLLEYKTA
220
STMENDEESV
230
KEASDFVGMM
240
LAAATSKTCA
250
TTIAYPHEVV
260
RTRLREEGTK
270
YRSFFQTLSL
280
LVQEEGYGSL
290
YRGLTTHLVR
300
QIPNTAIMMA
310
TYELVVYLLN
G
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0015218 |
pyrimidine nucleotide transmembrane transporter activity |
| Biological Process |
GO:1990519 |
pyrimidine nucleotide import into mitochondrion |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.