Search Results

Overview

Uniprot ID	Q96CT7
Protein Name	Coiled-coil domain-containing protein 124
Gene Name	CCDC124
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
11	KFQGENTKSAAARAR
4	****MPKKFQGENTK
82	EEEDSKLKGGKAPRV
94	PRVATSSKVTRAQIE

Function

Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage (PubMed:32687489). Also required for proper progression of late cytokinetic stages (PubMed:23894443)

Protein Sequence

10 MPKKFQGENT 20 KSAAARARRA 30 EAKAAADAKK 40 QKELEDAYWK 50 DDDKHVMRKE 60 QRKEEKEKRR 70 LDQLERKKET 80 QRLLEEEDSK 90 LKGGKAPRVA 100 TSSKVTRAQI 110 EDTLRRDHQL 120 REAPDTAEKA 130 KSHLEVPLEE 140 NVNRRVLEEG 150 SVEARTIEDA 160 IAVLSVAEEA 170 ADRHPERRMR 180 AAFTAFEEAQ 190 LPRLKQENPN 200 MRLSQLKQLL 210 KKEWLRSPDN 220 PMNQRAVPFN APK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0030496	midbody
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003713	transcription coactivator activity
Biological Process	GO:0051301	cell division
Biological Process	GO:0006366	transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.