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Overview

Uniprot IDQ96D46
Protein Name60S ribosomal export protein NMD3
Gene NameNMD3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
454 EEDEAIRKNVNIYRD

Function

Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit

Protein Sequence

10 MEYMAESTDR 20 SPGHILCCEC 30 GVPISPNPAN 40 ICVACLRSKV 50 DISQGIPKQV 60 SISFCKQCQR 70 YFQPPGTWIQ 80 CALESRELLA 90 LCLKKIKAPL 100 SKVRLVDAGF 110 VWTEPHSKRL 120 KVKLTIQKEV 130 MNGAILQQVF 140 VVDYVVQSQM 150 CGDCHRVEAK 160 DFWKAVIQVR 170 QKTLHKKTFY 180 YLEQLILKYG 190 MHQNTLRIKE 200 IHDGLDFYYS 210 SKQHAQKMVE 220 FLQCTVPCRY 230 KASQRLISQD 240 IHSNTYNYKS 250 TFSVEIVPIC 260 KDNVVCLSPK 270 LAQSLGNMNQ 280 ICVCIRVTSA 290 IHLIDPNTLQ 300 VADIDGSTFW 310 SHPFNSLCHP 320 KQLEEFIVME 330 CSIVQDIKRA 340 AGAGMISKKH 350 TLGEVWVQKT 360 SEMNTDKQYF 370 CRTHLGHLLN 380 PGDLVLGFDL 390 ANCNLNDEHV 400 NKMNSDRVPD 410 VVLIKKSYDR 420 TKRQRRRNWK 430 LKELAREREN 440 MDTDDERQYQ 450 DFLEDLEEDE 460 AIRKNVNIYR 470 DSAIPVESDT 480 DDEGAPRISL 490 AEMLEDLHIS 500 QDATGEEGAS MLT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0043023 ribosomal large subunit binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:1904751 positive regulation of protein localization to nucleolus
Biological Process GO:1902680 positive regulation of RNA biosynthetic process
Biological Process GO:0015031 protein transport
Biological Process GO:0000055 ribosomal large subunit export from nucleus

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.