Search Results

Overview

Uniprot IDQ96D71
Protein NameRalBP1-associated Eps domain-containing protein 1
Gene NameREPS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
105 LPRFVASKNEQESRH

Function

May coordinate the cellular actions of activated EGF receptors and Ral-GTPases

Protein Sequence

10 MEGLTLSDAE 20 QKYYSDLFSY 30 CDIESTKKVV 40 VNGRVLELFR 50 AAQLPNDVVL 60 QIMELCGATR 70 LGYFGRSQFY 80 IALKLVAVAQ 90 SGFPLRVESI 100 NTVKDLPLPR 110 FVASKNEQES 120 RHAASYSSDS 130 ENQGSYSGVI 140 PPPPGRGQVK 150 KGSVSHDTVQ 160 PRTSADAQEP 170 ASPVVSPQQS 180 PPTSPHTWRK 190 HSRHPSGGNS 200 ERPLAGPGPF 210 WSPFGEAQSG 220 SSAGDAVWSG 230 HSPPPPQENW 240 VSFADTPPTS 250 TLLTMHPASV 260 QDQTTVRTVA 270 SATTAIEIRR 280 QSSSYDDPWK 290 ITDEQRQYYV 300 NQFKTIQPDL 310 NGFIPGSAAK 320 EFFTKSKLPI 330 LELSHIWELS 340 DFDKDGALTL 350 DEFCAAFHLV 360 VARKNGYDLP 370 EKLPESLMPK 380 LIDLEDSADV 390 GDQPGEVGYS 400 GSPAEAPPSK 410 SPSMPSLNQT 420 WPELNQSSEQ 430 WETFSERSSS 440 SQTLTQFDSN 450 IAPADPDTAI 460 VHPVPIRMTP 470 SKIHMQEMEL 480 KRTGSDHTNP 490 TSPLLVKPSD 500 LLEENKINSS 510 VKFASGNTVA 520 DGYSSSDSFT 530 SDPEQIGSNV 540 TRQRSHSGTS 550 PDNTAPPPPP 560 PRPQPSHSRS 570 SSLDMNRTFT 580 VTTGQQQAGV 590 VAHPPAVPPR 600 PQPSQAPGPA 610 VHRPVDADGL 620 ITHTSTSPQQ 630 IPEQPNFADF 640 SQFEVFAASN 650 VNDEQDDEAE 660 KHPEVLPAEK 670 ASDPASSLRV 680 AKTDSKTEEK 690 TAASAPANVS 700 KGTTPLAPPP 710 KPVRRRLKSE 720 DELRPEVDEH 730 TQKTGVLAAV 740 LASQPSIPRS 750 VGKDKKAIQA 760 SIRRNKETNT 770 VLARLNSELQ 780 QQLKDVLEER 790 ISLEVQLEQL RPFSHL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0017124 SH3 domain binding
Biological Process GO:0006897 endocytosis
Biological Process GO:0016197 endosomal transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.