Search Results
Overview
| Uniprot ID | Q96DB2 |
|---|---|
| Protein Name | Histone deacetylase 11 |
| Gene Name | HDAC11 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 41 | LHPFDAGKWGKVINF |
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes
Protein Sequence
10
MLHTTQLYQH
20
VPETRWPIVY
30
SPRYNITFMG
40
LEKLHPFDAG
50
KWGKVINFLK
60
EEKLLSDSML
70
VEAREASEED
80
LLVVHTRRYL
90
NELKWSFAVA
100
TITEIPPVIF
110
LPNFLVQRKV
120
LRPLRTQTGG
130
TIMAGKLAVE
140
RGWAINVGGG
150
FHHCSSDRGG
160
GFCAYADITL
170
AIKFLFERVE
180
GISRATIIDL
190
DAHQGNGHER
200
DFMDDKRVYI
210
MDVYNRHIYP
220
GDRFAKQAIR
230
RKVELEWGTE
240
DDEYLDKVER
250
NIKKSLQEHL
260
PDVVVYNAGT
270
DILEGDRLGG
280
LSISPAGIVK
290
RDELVFRMVR
300
GRRVPILMVT
310
SGGYQKRTAR
320
IIADSILNLF
330
GLGLIGPESP
340
SVSAQNSDTP
LLPPAVP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0004407 | histone deacetylase activity |
| Molecular Function | GO:0141221 | histone deacetylase activity, hydrolytic mechanism |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0040029 | epigenetic regulation of gene expression |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.