Search Results
Overview
| Uniprot ID | Q96DC8 |
|---|---|
| Protein Name | Enoyl-CoA hydratase domain-containing protein 3, mitochondrial |
| Gene Name | ECHDC3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 130 | EVFQTCSKVMMHIRN |
| 239 | ETMRIARKIASLSRP |
| 252 | RPVVSLGKATFYKQL |
| 295 | TAFLQKRKPVWSHEP |
| 65 | NIVLSNPKKRNALSL |
Function
May play a role in fatty acid biosynthesis and insulin sensitivity
Protein Sequence
10
MAAVAVLRAF
20
GASGPMCLRR
30
GPWAQLPARF
40
CSRDPAGAGR
50
RESEPRPTSA
60
RQLDGIRNIV
70
LSNPKKRNAL
80
SLAMLKSLQS
90
DILHDADSND
100
LKVIIISAEG
110
PVFSSGHDLK
120
ELTEEQGRDY
130
HAEVFQTCSK
140
VMMHIRNHPV
150
PVIAMVNGLA
160
AAAGCQLVAS
170
CDIAVASDKS
180
SFATPGVNVG
190
LFCSTPGVAL
200
ARAVPRKVAL
210
EMLFTGEPIS
220
AQEALLHGLL
230
SKVVPEAELQ
240
EETMRIARKI
250
ASLSRPVVSL
260
GKATFYKQLP
270
QDLGTAYYLT
280
SQAMVDNLAL
290
RDGQEGITAF
300
LQKRKPVWSH
EPV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004300 | enoyl-CoA hydratase activity |
| Molecular Function | GO:0016836 | hydro-lyase activity |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:1900078 | positive regulation of cellular response to insulin stimulus |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.