Overview
| Uniprot ID | Q96DE5 |
|---|
| Protein Name | Anaphase-promoting complex subunit 16 |
|---|
| Gene Name | ANAPC16 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 33 |
SDLAPPRKALFTYPK |
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:20360068, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:20360068). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861)
Protein Sequence
10
MAASSSSSSA
20
GGVSGSSVTG
30
SGFSVSDLAP
40
PRKALFTYPK
50
GAGEMLEDGS
60
ERFLCESVFS
70
YQVASTLKQV
80
KHDQQVARME
90
KLAGLVEELE
100
ADEWRFKPIE
110
QLLGFTPSSG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005680 |
anaphase-promoting complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Biological Process |
GO:0031145 |
anaphase-promoting complex-dependent catabolic process |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0141198 |
protein branched polyubiquitination |
| Biological Process |
GO:0070979 |
protein K11-linked ubiquitination |
| Biological Process |
GO:0070936 |
protein K48-linked ubiquitination |
| Biological Process |
GO:0016567 |
protein ubiquitination |
| Biological Process |
GO:0051445 |
regulation of meiotic cell cycle |
| Biological Process |
GO:0007346 |
regulation of mitotic cell cycle |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.