Search Results

Overview

Uniprot ID	Q96DG6
Protein Name	Carboxymethylenebutenolidase homolog
Gene Name	CMBL
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
115	REISAILKYLKQQCH
118	SAILKYLKQQCHAQK
193	DVSLLTQKLKEHCKV
199	QKLKEHCKVEYQIKT
205	CKVEYQIKTFSGQTH
218	THGFVHRKREDCSPA
227	EDCSPADKPYIDEAR
31	EVQVEHIKAYVTKSP
36	HIKAYVTKSPVDAGK

Function

Cysteine hydrolase whose endogenous substrates and physiological function are unknown. Catalyzes the hydrolytic activation of several ester-based prodrugs, by cleaving the dioxolone ring to yield their respective active metabolites, diacetyl and CO2. Can thus convert the prodrugs Olmesartan medoxomil and Azilsartan medoxomil into their active metabolites (Olmesartan and Azilsartan), two angiotensin receptor blockers. Is also able to activate beta-lactam antibiotics Faropenem medoxomil and Lenampicillin

Protein Sequence

10 MANEAYPCPC 20 DIGHRLEYGG 30 LGREVQVEHI 40 KAYVTKSPVD 50 AGKAVIVIQD 60 IFGWQLPNTR 70 YIADMISGNG 80 YTTIVPDFFV 90 GQEPWDPSGD 100 WSIFPEWLKT 110 RNAQKIDREI 120 SAILKYLKQQ 130 CHAQKIGIVG 140 FCWGGTAVHH 150 LMMKYSEFRA 160 GVSVYGIVKD 170 SEDIYNLKNP 180 TLFIFAENDV 190 VIPLKDVSLL 200 TQKLKEHCKV 210 EYQIKTFSGQ 220 THGFVHRKRE 230 DCSPADKPYI 240 DEARRNLIEW LNKYM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Molecular Function	GO:0016787	hydrolase activity
Biological Process	GO:0006805	xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.