Search Results
Overview
| Uniprot ID | Q96DM3 |
|---|---|
| Protein Name | Regulator of MON1-CCZ1 complex |
| Gene Name | RMC1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 202 | IELPAAPKSTKPSLS |
Function
Component of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162)
Protein Sequence
10
MGEEDYYLEL
20
CERPVQFEKA
30
NPVNCVFFDE
40
ANKQVFAVRS
50
GGATGVVVKG
60
PDDRNPISFR
70
MDDKGEVKCI
80
KFSLENKILA
90
VQRTSKTVDF
100
CNFIPDNSQL
110
EYTQECKTKN
120
ANILGFCWTS
130
STEIVFITDQ
140
GIEFYQVLPE
150
KRSLKLLKSH
160
NLNVNWYMYC
170
PESAVILLST
180
TVLENVLQPF
190
HFRAGTMSKL
200
PKFEIELPAA
210
PKSTKPSLSE
220
RDIAMATIYG
230
QLYVLFLRHH
240
SRTSNSTGAE
250
VVLYHLPREG
260
ACKKMHILKL
270
NRTGKFALNV
280
VDNLVVVHHQ
290
DTETSVIFDI
300
KLRGEFDGSV
310
TFHHPVLPAR
320
SIQPYQIPIT
330
GPAAVTSQSP
340
VPCKLYSSSW
350
IVFQPDIIIS
360
ASQGYLWNLQ
370
VKLEPIVNLL
380
PDKGRLMDFL
390
LQRKECKMVI
400
LSVCSQMLSE
410
SDRASLPVIA
420
TVFDKLNHEY
430
KKYLDAEQSY
440
AMAVEAGQSR
450
SSPLLKRPVR
460
TQAVLDQSDV
470
YTHVLSAFVE
480
KKEMPHKFVI
490
AVLMEYIRSL
500
NQFQIAVQHY
510
LHELVIKTLV
520
QHNLFYMLHQ
530
FLQYHVLSDS
540
KPLACLLLSL
550
ESFYPPAHQL
560
SLDMLKRLST
570
ANDEIVEVLL
580
SKHQVLAALR
590
FIRGIGGHDN
600
ISARKFLDAA
610
KQTEDNMLFY
620
TIFRFFEQRN
630
QRLRGSPNFT
640
PGEHCEEHVA
650
FFKQIFGDQA
LMRPTTF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0035658 | Mon1-Ccz1 complex |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0010506 | regulation of autophagy |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.