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Overview

Uniprot IDQ96DR7
Protein NameRho guanine nucleotide exchange factor 26
Gene NameARHGEF26
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
118 PKSPKLPKAVPGGSP
263 ASEIKISKSNNQNVE

Function

Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry

Protein Sequence

10 MDGESEVDFS 20 SNSITPLWRR 30 RSIPQPHQVL 40 GRSKPRPQSY 50 QSPNGLLITD 60 FPVEDGGTLL 70 AAQIPAQVPT 80 ASDSRTVHRS 90 PLLLGAQRRA 100 VANGGTASPE 110 YRAASPRLRR 120 PKSPKLPKAV 130 PGGSPKSPAN 140 GAVTLPAPPP 150 PPVLRPPRTP 160 NAPAPCTPEE 170 DLTGLTASPV 180 PSPTANGLAA 190 NNDSPGSGSQ 200 SGRKAKDPER 210 GLFPGPQKSS 220 SEQKLPLQRL 230 PSQENELLEN 240 PSVVLSTNSP 250 AALKVGKQQI 260 IPKSLASEIK 270 ISKSNNQNVE 280 PHKRLLKVRS 290 MVEGLGGPLG 300 HAGEESEVDN 310 DVDSPGSLRR 320 GLRSTSYRRA 330 VVSGFDFDSP 340 TSSKKKNRMS 350 QPVLKVVMED 360 KEKFSSLGRI 370 KKKMLKGQGT 380 FDGEENAVLY 390 QNYKEKALDI 400 DSDEESEPKE 410 QKSDEKIVIH 420 HKPLRSTWSQ 430 LSAVKRKGLS 440 QTVSQEERKR 450 QEAIFEVISS 460 EHSYLLSLEI 470 LIRMFKNSKE 480 LSDTMTKTER 490 HHLFSNITDV 500 CEASKKFFIE 510 LEARHQNNIF 520 IDDISDIVEK 530 HTASTFDPYV 540 KYCTNEVYQQ 550 RTLQKLLATN 560 PSFKEVLSRI 570 ESHEDCRNLP 580 MISFLILPMQ 590 RVTRLPLLMD 600 TICQKTPKDS 610 PKYEVCKRAL 620 KEVSKLVRLC 630 NEGARKMERT 640 EMMYTINSQL 650 EFKIKPFPLV 660 SSSRWLVKRG 670 ELTAYVEDTV 680 LFSRRTSKQQ 690 VYFFLFNDVL 700 IITKKKSEES 710 YNVNDYSLRD 720 QLLVESCDNE 730 ELNSSPGKNS 740 STMLYSRQSS 750 ASHLFTLTVL 760 SNHANEKVEM 770 LLGAETQSER 780 ARWITALGHS 790 SGKPPADRTS 800 LTQVEIVRSF 810 TAKQPDELSL 820 QVADVVLIYQ 830 RVSDGWYEGE 840 RLRDGERGWF 850 PMECAKEITC 860 QATIDKNVER 870 MGRLLGLETN V

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001726 ruffle
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process GO:0032956 regulation of actin cytoskeleton organization

Reference

PMID: N/A