Search Results

Overview

Uniprot ID	Q96DT7
Protein Name	Zinc finger and BTB domain-containing protein 10
Gene Name	ZBTB10
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
240	HFPLARPKSLMQKLQ
497	LSSSRDQKIASFWAT
573	QGIQETGKTRRKNQT

Function

May be involved in transcriptional regulation

Protein Sequence

10 MSFSEMNRRT 20 LAFRGGGLVT 30 ASGGGSTNNN 40 AGGEASAWPP 50 QPQPRQPPPP 60 APPALQPPNG 70 RGADEEVELE 80 GLEPQDLEAS 90 AGPAAGAAEE 100 AKELLLPQDA 110 GGPTSLGGGA 120 GGPLLAERNR 130 RTLAFRGGGG 140 GGLGNNGSSR 150 GRPETSVWPL 160 RHFNGRGPAT 170 VDLELDALEG 180 KELMQDGASL 190 SDSTEDEEEG 200 ASLGDGSGAE 210 GGSCSSSRRS 220 GGDGGDEVEG 230 SGVGAGEGET 240 VQHFPLARPK 250 SLMQKLQCSF 260 QTSWLKDFPW 270 LRYSKDTGLM 280 SCGWCQKTPA 290 DGGSVDLPPV 300 GHDELSRGTR 310 NYKKTLLLRH 320 HVSTEHKLHE 330 ANAQESEIPS 340 EEGYCDFNSR 350 PNENSYCYQL 360 LRQLNEQRKK 370 GILCDVSIVV 380 SGKIFKAHKN 390 ILVAGSRFFK 400 TLYCFSNKES 410 PNQNNTTHLD 420 IAAVQGFSVI 430 LDFLYSGNLV 440 LTSQNAIEVM 450 TVASYLQMSE 460 VVQTCRNFIK 470 DALNISIKSE 480 APESVVVDYN 490 NRKPVNRDGL 500 SSSRDQKIAS 510 FWATRNLTNL 520 ASNVKIENDG 530 CNVDEGQIEN 540 YQMNDSSWVQ 550 DGSPEMAENE 560 SEGQTKVFIW 570 NNMGSQGIQE 580 TGKTRRKNQT 590 TKRFIYNIPP 600 NNETNLEDCS 610 VMQPPVAYPE 620 ENTLLIKEEP 630 DLDGALLSGP 640 DGDRNVNANL 650 LAEAGTSQDG 660 GDAGTSHDFK 670 YGLMPGPSND 680 FKYGLIPGTS 690 NDFKYGLIPG 700 ASNDFKYGLL 710 PESWPKQETW 720 ENGESSLIMN 730 KLKCPHCSYV 740 AKYRRTLKRH 750 LLIHTGVRSF 760 SCDICGKLFT 770 RREHVKRHSL 780 VHKKDKKYKC 790 MVCKKIFMLA 800 ASVGIRHGSR 810 RYGVCVDCAD 820 KSQPGGQEGV 830 DQGQDTEFPR 840 DEEYEENEVG 850 EADEELVDDG 860 EDQNDPSRWD 870 ESGEVCMSLD D

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000781	chromosome, telomeric region
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function	GO:0042162	telomeric DNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.