Search Results
Overview
| Uniprot ID | Q96E29 |
|---|---|
| Protein Name | Transcription termination factor 3, mitochondrial |
| Gene Name | MTERF3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 189 | LDFEKDIKQMLLFLK |
Function
Binds promoter DNA and regulates initiation of transcription (PubMed:17662942). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity)
Protein Sequence
10
MALSAQQIPR
20
WFNSVKLRSL
30
INAAQLTKRF
40
TRPARTLLHG
50
FSAQPQISSD
60
NCFLQWGFKT
70
YRTSSLWNSS
80
QSTSSSSQEN
90
NSAQSSLLPS
100
MNEQSQKTQN
110
ISSFDSELFL
120
EELDELPPLS
130
PMQPISEEEA
140
IQIIADPPLP
150
PASFTLRDYV
160
DHSETLQKLV
170
LLGVDLSKIE
180
KHPEAANLLL
190
RLDFEKDIKQ
200
MLLFLKDVGI
210
EDNQLGAFLT
220
KNHAIFSEDL
230
ENLKTRVAYL
240
HSKNFSKADV
250
AQMVRKAPFL
260
LNFSVERLDN
270
RLGFFQKELE
280
LSVKKTRDLV
290
VRLPRLLTGS
300
LEPVKENMKV
310
YRLELGFKHN
320
EIQHMITRIP
330
KMLTANKMKL
340
TETFDFVHNV
350
MSIPHHIIVK
360
FPQVFNTRLF
370
KVKERHLFLT
380
YLGRAQYDPA
390
KPNYISLDKL
400
VSIPDEIFCE
410
EIAKASVQDF
EKFLKTL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0061668 | mitochondrial ribosome assembly |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:1903108 | regulation of mitochondrial transcription |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.