Search Results
Overview
| Uniprot ID | Q96E40 |
|---|---|
| Protein Name | Sperm acrosome-associated protein 9 |
| Gene Name | SPACA9 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | NNLLEKCKTLVSQSN |
| 16 | RSIEQKYKLFQQQQL |
Function
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated spermatozoa (PubMed:36191189). Forms an extensive interaction network cross-linking the lumen of axonemal doublet microtubules (By similarity)
Protein Sequence
10
MNEVKESLRS
20
IEQKYKLFQQ
30
QQLTFTAALE
40
HCRENAHDKI
50
RPISSIGQVQ
60
SYMEHYCNSS
70
TDRRVLLMFL
80
DICSELNKLC
90
QHFEAVHSGT
100
PVTNNLLEKC
110
KTLVSQSNDL
120
SSLRAKYPHD
130
VVNHLSCDEA
140
RNHYGGVVSL
150
IPLILDLMKE
160
WIAHSEKLPR
170
KVLQHVSEPQ
180
AHQESTRGAA
190
RPAQAIGTQP
200
RATKHKCRQL
210
TKASLKPRGC
220
SKPPWRPPGG
KL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0005879 | axonemal microtubule |
| Cellular Component | GO:0160110 | axonemal microtubule doublet inner sheath |
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0097546 | ciliary base |
| Cellular Component | GO:0005881 | cytoplasmic microtubule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0097229 | sperm end piece |
| Cellular Component | GO:0036126 | sperm flagellum |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Biological Process | GO:0035082 | axoneme assembly |
| Biological Process | GO:0030317 | flagellated sperm motility |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.