Overview
| Uniprot ID | Q96EK4 |
|---|
| Protein Name | THAP domain-containing protein 11 |
|---|
| Gene Name | THAP11 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 28 |
LHFYTFPKDAELRRL |
Function
Transcription factor, which has both transcriptional activation and repression activities (PubMed:31905202). Also modulates chromatin accessibility (PubMed:38361031). In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (PubMed:26416877). May regulate the expression of genes that encode both cytoplasmic and mitochondrial ribosomal proteins (By similarity). Required for normal mitochondrial development and function. Regulates mitochondrial gene expression, including that of components of the electron transport chain (By similarity). Involved in the maintainance of pluripotency in early embryonic cells, possibly through its action on mitochondrial maturation which is required to meet high energy demands of these cells (By similarity). Required for early development of retina, preventing premature exit of retinal progenitor cells from the cell cycle. This effect may also be mediated by its action on mitochondria (By similarity). Through the regulation of MMACHC gene expression, controls cobalamin metabolism (PubMed:28449119, PubMed:31905202). Required for normal brain development and neural precursor differentiation (By similarity). Involved in cell growth (PubMed:31905202)
Protein Sequence
10
MPGFTCCVPG
20
CYNNSHRDKA
30
LHFYTFPKDA
40
ELRRLWLKNV
50
SRAGVSGCFS
60
TFQPTTGHRL
70
CSVHFQGGRK
80
TYTVRVPTIF
90
PLRGVNERKV
100
ARRPAGAAAA
110
RRRQQQQQQQ
120
QQQQQQQQQQ
130
QQQQQQQQQQ
140
QQSSPSASTA
150
QTAQLQPNLV
160
SASAAVLLTL
170
QATVDSSQAP
180
GSVQPAPITP
190
TGEDVKPIDL
200
TVQVEFAAAE
210
GAAAAAAASE
220
LQAATAGLEA
230
AECPMGPQLV
240
VVGEEGFPDT
250
GSDHSYSLSS
260
GTTEEELLRK
270
LNEQRDILAL
280
MEVKMKEMKG
290
SIRHLRLTEA
300
KLREELREKD
310
RLLAMAVIRK
KHGM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0001046 |
core promoter sequence-specific DNA binding |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.