Search Results

Overview

Uniprot IDQ96EP5
Protein NameDAZ-associated protein 1
Gene NameDAZAP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
103 RPKEGWQKGPRSDNS
59 GFGFVKFKDPNCVGT

Function

RNA-binding protein, which may be required during spermatogenesis

Protein Sequence

10 MNNSGADEIG 20 KLFVGGLDWS 30 TTQETLRSYF 40 SQYGEVVDCV 50 IMKDKTTNQS 60 RGFGFVKFKD 70 PNCVGTVLAS 80 RPHTLDGRNI 90 DPKPCTPRGM 100 QPERTRPKEG 110 WQKGPRSDNS 120 KSNKIFVGGI 130 PHNCGETELR 140 EYFKKFGVVT 150 EVVMIYDAEK 160 QRPRGFGFIT 170 FEDEQSVDQA 180 VNMHFHDIMG 190 KKVEVKRAEP 200 RDSKSQAPGQ 210 PGASQWGSRV 220 VPNAANGWAG 230 QPPPTWQQGY 240 GPQGMWVPAG 250 QAIGGYGPPP 260 AGRGAPPPPP 270 PFTSYIVSTP 280 PGGFPPPQGF 290 PQGYGAPPQF 300 SFGYGPPPPP 310 PDQFAPPGVP 320 PPPATPGAAP 330 LAFPPPPSQA 340 APDMSKPPTA 350 QPDFPYGQYA 360 GYGQDLSGFG 370 QGFSDPSQQP 380 PSYGGPSVPG 390 SGGPPAGGSG 400 FGRGQNHNVQ GFHPYRR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0003730 mRNA 3'-UTR binding
Molecular Function GO:0034046 poly(G) binding
Molecular Function GO:0008266 poly(U) RNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0035613 RNA stem-loop binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0048026 positive regulation of mRNA splicing, via spliceosome
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.